You configure a protection domain by using Async DR feature (up to 1-hour RPO) or NearSync DR (up to 1-minute RPO ) by defining a group of entities (VMs and volume groups) that are backed up locally on a cluster and optionally replicated to one or more remote sites.

See the DR best practices guide from https://portal.nutanix.com/#/page/solutions for guidance to set up DR in your environment.